Table 7. Patient characteristics.

Group A: conventional (non-chronomodulated) chemotherapy; group B: chronomodulated chemotherapy

Study	Sample size	Group A	Group B	Age, median (range)		Gender (M:F)		Performance status (WHO)
				Group A	Group B	Group A	Group B	Group A	Group B
Ramanathan et al. 2008 [43]	129	104	25	Two arms: 60 (27–78) and 55 (25–75)	61 (43:81)	59:22, 72.8% males	18:7, 72% males	0:55 (67.9%) 1:25 (30.8%) 2:1 (1%)	0:15 (60%) 1:10 (40%) 2:0
Huang et al. 2006 [46]	42	20	22	47.2	53.4	8:12, 40% males	11:11, 50% males	Not specified	Not specified
Giacchetti et al. 2006 [44]	564	282	282	62 (31.8–76)	62 (22.3–76)	170:112, 61% males	168:114, 59.5% males	0:139 (49%) 1:116 (41%) 2:27 (10%)	0:134 (47%) 1:115 (41%) 2:33 (12%)
Garufi et al. 2006 [24]	68	33	35	62 (35–77)	61 (28–77)	19:14, 57.5% males	22:13, 62.8% males	0:22 (67%) 1:9 (27%) 2:2 (6%)	0:22 (63%) 1:12 (34%) 2:1 (3%)
Focan et al. 1997 [45]	56	27	29	58 (34–75)	64 (44–75)	17:10, 63% males	18:11, 62% males	0:11 (41%) 1:14 (52%) 2:2 (7%)	0:12 (41%) 1:16 (56%) 2:1 (3%)
Lévi et al. 1997 [29]	186	93	93	61 (29–75)	61 (22–75)	60:33, 64.5% males	52:41, 56% males	0:50 (54%) 1:34 (37%) 2-3:9 (10%)	0:49 (53%) 1:30 (32%) 2-3:14 (15%)
Lévi et al. 1994 [35]	92	47	45	60 (34–73)	60 (31–73)	27:20, 57.4% males	20:25, 44.4% males	0:14 (30%) 1:27 (57%) 2:6 (13%)	0:19 (42%) 1:23 (51%) 2: 3 (7%)