Table 5. The number of essential proteins detected by the six centrality methods under different strategies for the new DIP dataset (top 600).
| Ontology | SSMs | Network | BC | DC | EC | NC | SC | aveNC |
|---|---|---|---|---|---|---|---|---|
| original PPI | 239 | 274 | 160 | 318 | 163 | 72 | ||
| BP | Jiang | GO-PPI | 285 | 347 | 337 | 351 | 333 | 258 |
| Lin | GO-PPI | 275 | 350 | 332 | 346 | 329 | 228 | |
| Rel | GO-PPI | 282 | 358 | 345 | 349 | 345 | 261 | |
| Resnik | GO-PPI | 355 | 370 | 348 | 351 | 345 | 340 | |
| Wang | GO-PPI | 285 | 349 | 336 | 352 | 349 | 285 | |
| CC | Jiang | GO-PPI | 226 | 289 | 148 | 315 | 201 | 123 |
| Lin | GO-PPI | 253 | 309 | 203 | 311 | 293 | 171 | |
| Rel | GO-PPI | 261 | 319 | 279 | 303 | 294 | 212 | |
| Resnik | GO-PPI | 298 | 309 | 280 | 308 | 321 | 301 | |
| Wang | GO-PPI | 252 | 294 | 216 | 340 | 272 | 94 | |
| MF | Jiang | GO-PPI | 244 | 276 | 261 | 285 | 256 | 226 |
| Lin | GO-PPI | 260 | 276 | 254 | 288 | 260 | 230 | |
| Rel | GO-PPI | 265 | 286 | 278 | 286 | 279 | 241 | |
| Resnik | GO-PPI | 231 | 250 | 239 | 242 | 248 | 240 | |
| Wang | GO-PPI | 242 | 282 | 256 | 306 | 225 | 171 |