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. 2023 Apr 21;9(16):eadg6593. doi: 10.1126/sciadv.adg6593

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Fig. 1. — In wild-type Drosophila (top), CBP/p300 (Nejire) and Gcn5 regulate the expression of distinct gene sets and catalyze H3K18ac/H3K27ac and H3K9ac, respectively. When wild-type Nejire and Gcn5 are replaced with catalytically dead (CD) mutants, histone acetylation is lost from their target genes; however, these genes still become activated during ZGA. By contrast, when Nejire and Gcn5 protein is eliminated by RNAi (bottom), target genes fail to activate. DUB, deubiquitinase module; SF3B, splicing factor 3B module; TF, transcription factor; TRRAP, transformation/transcription domain–associated protein module.