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. 2023 Apr 21;9(16):eadg6593. doi: 10.1126/sciadv.adg6593

Fig. 2. Gene activation in the absence of H3K27 modifications.

Fig. 2.

In wild-type mESCs and Drosophila, PRC2 maintains target gene silencing by catalyzing methylation of the H3K27 residue. Upon genetic elimination of PRC2 (middle), its targets acquire CBP/p300-catalyzed H3K27ac and become transcriptionally activated, suggesting that the possibility that H3K27ac could instruct activation. However, replacement of H3K27 with an arginine residue (bottom) revealed that PRC2 repressed genes are activated even in the absence of H3K27ac.