Table 3.
Summary of wound complications by treatment arms.
| Dose-Finding Phase (Chemotherapy Cohort, n=2) | Dose-Finding Phase (RT/non-Chemotherapy Cohort, n=9) | Regimen A (RT + chemotherapy + pazopanib, n=17) |
Regimen B (RT + chemotherapy, n=5) | Regimen C (RT + pazopanib, n=1) | Regimen D (RT, n=1) | |
|---|---|---|---|---|---|---|
| Wound complication grade | ||||||
| Grade I | 1 (50%) | 2 (22.22%) | 6 (35.29%) | 0 | 1 (100%) | 0 |
| Grade II | 0 | 1 (11.11%) | 3 (17.65%) | 1 (20.00%) | 0 | 0 |
| Grade III (IIIa, IIIb, IIIx) | 1 (50%) | 6 (66.67%) | 8 (47.06%) | 4 (80.00%) | 0 | 1 (100%) |
| Time from surgery to wound complication, Median (range in days) | 38.5 (33–44) |
32 (0–113) |
38 (0–220) |
14 (0–70) |
28 (28–28) |
62 (62–62) |
| Delay in treatment (>14 days after surgery to restart of chemotherapy) | 2 (100%) | 6 (66.67%) | 14 (82.35%) | 2 (40.00%) | 1 (100%) | 0 |
RT = radiation therapy