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. 2023 Feb 1;29(2):293–319. doi: 10.3350/cmh.2022.0425

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Copyright © 2023 by The Korean Association for the Study of the Liver

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Main findings from the studies included in this systematic review describing modulatory effects associated to NRP1 and NRP2 in HCC. Specific modulatory effects exerted by both NRPs are graphically shown, together with correlations observed in different cellular processes and molecular mechanisms. α-SMA, α smooth muscle actin; CSC, cancer stem cell; DFS, disease-free survival; IFN-β, interferon beta; IFN-γ, interferon gamma; OS, overall survival; PFS, progression-free survival; RFS, recurrence-free survival; TFAP4, transcription factor activating enhancer binding protein 4; TGF-β, transforming growth factor beta; TNF-α, tumoral necrosis factor-α; VEGF, vascular endothelial growth factor.