Dependence of AAV serotype on AAP. Green boxes indicate AAP-independent serotypes (complete absence of AAP resulted in » 1% of WT titer). Yellow boxes indicate AAPC-independent serotypes (absence of the C-terminal two-thirds of AAP resulted in >10% of WT titer). Red boxes indicate AAP-dependent serotypes (complete absence of AAP resulted in ∼1% of WT titer) [98].