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. 2023 Mar 24;26(4):106495. doi: 10.1016/j.isci.2023.106495

Figure 2.

Figure 2

Chemerin knockout mice had normal metabolic markers and cardiac function when fed a normal diet

Rarres2−/− and littermate WT mice were fed with normal diet for 20 weeks.

(A) Body weight of Rarres2−/− and littermate WT mice, n = 6.

(B and C) Measurement of GTT and ITT in Rarres2−/− and littermate WT mice, n = 6.

(D-H) Overnight fasted serum non-esterified fatty acid (NEFA), triglyceride (TG), total cholesterol (TC), HDL-C, and No HDL-C levels, n = 6, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗∗p < 0.0001, Rarres2−/− vs. littermate (I) Representative cross-sections of the hearts stained with H&E WGA and Oil-Red O staining and its quantification of cardiomyocyte sizes with WGA staining, n = 6, Rarrres2−/− vs. Littermate, scale bar = 50μm.

(J) Representative systolic and diastolic echocardiography images in Rarres2−/− and littermate mice.

(K-O) Left ventricular function assessed by E/A ratio, isovolumic relaxation time (IVRT), fractional shortening (FS), Left ventricular ejection fraction (LVEF), diastolic left ventricular internal dimension (LVID; D), n = 6.