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. 2023 Mar 24;26(4):106495. doi: 10.1016/j.isci.2023.106495

Figure 3.

Figure 3

Chemerin knockout exacerbated cardiac remodeling in HFD mice

Rarres2−/− and Littermate WT mice were subjected to high-fat diet feeding for 20 weeks.

(A) Body weight of two groups, n = 8 (B and C) Glucose tolerance test (GTT) and insulin tolerance test (ITT) were performed in Rarres2−/− and littermate mice. ∗p < 0.05, ∗∗p < 0.01, Rarres2−/− vs. littermate, n = 8.

(D) Representative cross-section of hearts stained for H&E, WGA, and Oil-Red O staining, its quantitative analysis of cardiomyocyte size (WGA staining). ∗p < 0.05, Rarrres2−/− vs. Littermate, n = 6, scale bar = 50μm.

(E) Representative systolic and diastolic echocardiography images of littermate and Rarres2−/− mice.

(F-J) Left ventricular function of littermate and Rarres2−/− in HFD, assessed by Left ventricular ejection fraction (LVEF), fractional shortening (FS), diastolic left ventricular internal dimension (LVID; D), E/A ratio, and isovolumic relaxation time (IVRT). ∗p < 0.05, ∗∗p < 0.01, Rarres2−/− vs. littermate, n = 8.