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. 2023 Apr 21;13:6528. doi: 10.1038/s41598-023-33848-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Irinotecan (IR) induces liver injury in mice. Mice were intraperitoneally injected with IR (50 mg/kg) or solvent (saline) every three days for 3 weeks. Effects of IR on (A) liver index, serum levels of (B) ALT and (C) AST, and (D) hepatic TG content. Data are presented as mean ± SD (n = 8), *P < 0.05 and **P < 0.01 compared with normal control (NC) group. (E) Liver sections were stained with H&E and Oil Red O to evaluate lipid accumulation. (F) Western blot analysis of SREBP-1c protein level in liver tissue. (G) Densitometric quantification of SREBP-1c. The blots were cut prior to hybridisation with indicated primary antibodies. Data are presented as mean ± SD (n = 6), **P < 0.01 compared with NC group.