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. 2023 Apr 21;13:6528. doi: 10.1038/s41598-023-33848-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Irinotecan (IR) aggrandizes hepatic oxidative stress and NLRP3 inflammasome activity in mice. Effects of IR on hepatic (A) MDA, (B) GSH-Px, (C) SOD and (D) CAT content. Data are presented as mean ± SD (n = 8), **P < 0.01 compared with normal control (NC) group. (E) Hepatic ROS level were determined by DHE staining. Red color is considered as ROS staining. (F) Western blot analysis of NLRP3, cleaved-Caspase1 and IL-1β protein levels in liver tissue. (G) Densitometric quantification of NLRP3, cleaved-Caspase1 and IL-1β. The blots were cut prior to hybridisation with indicated primary antibodies. Data are presented as mean ± SD (n = 6), **P < 0.01 compared with NC group.