Table 1.

PharmCAT runtimes for reference. The PharmCAT runtime and computing speed estimates are variables depending on the input sample size and variant size as well as the computing environment. VCF input to the PharmCAT has gone through the VCF preprocessor.

	Test sample Size	Computing environment	Speed (sec/sample)
VCF Preprocessor	50K	High-performance computing cluster*	1.2
PharmCAT	50K	High-performance computing cluster*	3.6
PharmCAT	50K	MacOS (2.9 GHz Intel Core i7)	2.1

^*For more information about the Stanford Sherlock high-performance computing cluster, please go to https://www.sherlock.stanford.edu/.