Table 1.
Demographic, clinical, and genetic characteristics of the study populations at baseline.
| Combined cohort (prevalent and incident GA) | Combined cohort with genetic data available | Incident GA cohort | Combined cohort with genetic data available (independent of RPD data availability) | |
|---|---|---|---|---|
| Participants | 563 (771 eyes) | 306 (420 eyes) | 413 (513 eyes) | 408 (548 eyes) |
| Age (years), mean (SD) | 74.8 (7.1) | 74.1 (7.1) | 74.5 (7.1) | 73.7 (7.2) |
| Female | 326 (57.9%) | 182 (59.5%) | 240 (58.1%) | 239 (58.6%) |
| Smoking status | ||||
| Never | 233 (41.4%) | 120 (39.2%) | 175 (42.4%) | 164 (40.2%) |
| Former | 298 (52.9%) | 171 (55.9%) | 213 (51.6%) | 222 (54.4%) |
| Current | 32 (5.7%) | 15 (4.9%) | 25 (6.1%) | 22 (5.4%) |
| Education level | ||||
| High school or less | 181 (32.1%) | 105 (34.3%) | 135 (32.7%) | 140 (34.3%) |
| At least some college | 277 (49.2%) | 143 (46.7%) | 204 (49.4%) | 191 (46.8%) |
| Postgraduate | 105 (18.7%) | 58 (19.0%) | 74 (17.9%) | 77 (18.9%) |
| Follow-up (years), mean (SD)* | 3.3 (1.5) | 3.3 (1.5) | 2.5 (1.2) | 3.2 (1.5) |
| Genetics data available | 306 (54.4%) | - | 236 (57.1%) | - |
| rs10490924 ARMS2 | ||||
| Unavailable | 257 | - | 177 | - |
| GG | 105 (34.3%) | 105 (34.3%) | 79 (33.5%) | 150 (36.8%) |
| GT | 137 (44.8%) | 137 (44.8%) | 108 (45.8%) | 172 (42.2%) |
| TT | 64 (20.9%) | 64 (20.9%) | 49 (20.8%) | 86 (21.1%) |
| Eyes | 771 | 420 | 513 | 548 |
| Cohort | ||||
| Prevalent | 258 (33.5%) | 127 (30.2%) | - | 160 (29.2%) |
| Incident | 513 (66.5%) | 293 (69.8%) | - | 388 (70.8%) |
| RPD present† | 114 (14.8%) | 67 (16.0%) | 103 (20.1%) | - |
| Central/noncentral GA | ||||
| Noncentral | 515 (66.8%) | 285 (67.9%) | 346 (67.4%) | 372 (67.9%) |
| Central | 256 (33.2%) | 135 (32.1%) | 167 (32.6%) | 176 (32.1%) |
| Configuration | ||||
| Small (single patch <1DA) | 411 (53.3%) | 228 (54.3%) | 311 (60.6%) | 300 (54.7%) |
| Multifocal | 171 (22.2%) | 95 (22.6%) | 118 (23.0%) | 122 (22.3%) |
| Horseshoe or ring | 27 (3.5%) | 17 (4.0%) | 9 (1.8%) | 23 (4.2%) |
| Solid | 137 (17.8%) | 69 (16.4%) | 63 (12.3%) | 92 (16.8%) |
| Indeterminate | 25 (3.2%) | 11 (2.6%) | 12 (2.3%) | 11 (2.0%) |
| Fellow eye with GA | ||||
| Unknown | 108 | 59 | 73 | 88 |
| No | 359 (54.2%) | 200 (55.4%) | 230 (52.3%) | 258 (56.1%) |
| Yes | 304 (45.8%) | 161 (44.6%) | 210 (47.7%) | 202 (43.9%) |
| GA area (mm2), mean (SD) | 2.2 (3.1) | 2.1 (3.0) | 1.6 (2.3) | 2.0 (2.9) |
| Proximity to fovea (μm), mean (SD) | 422.3 (473.1) | 419.6 (457.4) | 431.4 (472.8) | 432.4 (480.6) |
Abbreviations: DA=disc areas; GA=geographic atrophy; RPD=reticular pseudodrusen; SD=standard deviation
*
follow-up from baseline (for prevalent GA) or first GA appearance (for incident GA)
†
defined at baseline (for prevalent GA) or at/any time prior to first GA appearance (for incident GA)