. Author manuscript; available in PMC: 2024 May 1.

Published in final edited form as: Ophthalmology. 2022 Dec 6:S0161-6420(22)00932-0. doi: 10.1016/j.ophtha.2022.11.026

Table 4.

Geographic atrophy enlargement rates according to reticular pseudodrusen status and ARMS2 genotype, considered simultaneously.

RPD status or ARMS2 risk alleles^*	Estimate^† (mm/year)	95% CI (mm/year)	P^‡
RPD absence (n=353 eyes)	0.273	0.256–0.289	<0.0001
RPD presence (n=67 eyes)	0.379	0.329–0.430	<0.0001

0 (GG) (n=142 eyes)	0.224	0.198–0.250	<0.0001
1 (GT) (n=193 eyes)	0.287	0.263–0.310
2 (TT) (n=85 eyes)	0.307	0.273–0.341

Abbreviations: CI=confidence interval; RPD=reticular pseudodrusen

RPD status defined at study baseline for eyes with prevalent geographic atrophy (GA) and at first GA appearance for eyes with incident GA

^†

Mixed-model, repeated-measures regression with the square root of GA area as the dependent variable

^‡

P value for interaction between characteristic (RPD status or ARMS2 risk alleles) and years