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. Author manuscript; available in PMC: 2024 Apr 19.
Published in final edited form as: Neuron. 2023 Feb 13;111(8):1301–1315.e5. doi: 10.1016/j.neuron.2023.01.015

Figure 5. Increased release of astrocytic GABA after social deprivation.

Figure 5.

(A-B) Immunostaining for Maob and GABA in hippocampal astrocytes from Aldh1l1-GFP mice after GH or SH paradigms (n = 19-23 cells from 3 pairs of animals). Welch’s t-test.

(C) Representative traces measuring tonic GABA currents in CA1 pyramidal neurons in GH and SH cohorts treated with vehicle or HC.

(D-F) Quantification of tonic GABA current (D), sIPSC amplitude (E), and sIPSC frequency (F) from the same cohorts and experimental conditions. Two-way ANOVA, Tukey test.

(G) Representative traces measuring tonic GABA currents in CA1 pyramidal neurons in GH and SH cohorts with Cre or Cre+sgRNA.

(H-J) Quantification of tonic GABA current (H), sIPSC amplitude (I), and sIPSC frequency (J) from the same cohorts and experimental conditions. Two-way ANOVA, Tukey test.

*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.