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. Author manuscript; available in PMC: 2023 Apr 22.
Published in final edited form as: Nat Med. 2023 Mar 13;29(4):906–916. doi: 10.1038/s41591-023-02234-6

Extended Data Figure 6. Analyzing microbiome features associated with major cohort characteristics.

Extended Data Figure 6.

(A) Differential relative abundance analyses by log-fold changes and statistical testing by Mann-Whitney tests illustrated with volcano plots for species and metabolic pathways encoded in the fecal metagenomes: the log2 abundance in none | LR antibiotic samples (n = 79) / abundance in HR antibiotic samples (n = 16), versus the significance of the abundance difference. Metabolic pathways that have both p-value < 0.05 and absolute log2 fold change > 1 are shown in red. (B) Bar-plots indicating the fold-change of the top features revealed by the differential abundance analyses described in (A). (C and D) Differential abundance analyses for species and metabolic pathway composition comparing the German (n = 50 patients) and the US (n = 45 patients) cohort. Here, comparisons of fecal metagenomes for samples collected in the 3-weeks pre-CAR-T cell infusion window are shown. Group comparisons carried out by Mann-Whitney tests.