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. Author manuscript; available in PMC: 2023 Apr 22.
Published in final edited form as: Nat Med. 2023 Mar 13;29(4):906–916. doi: 10.1038/s41591-023-02234-6

Extended Data Figure 9. Summary of differentially abundant microbiome features by clinical variables and outcomes excluding baseline specimens collected while or within 2 weeks after exposure to high-risk antibiotics.

Extended Data Figure 9.

Heatmaps showing the associations between the species (A) and metabolic pathways (B) of the baseline gut microbiome and clinical parameters and major outcomes (Mann–Whitney tests, p-value < 0.05). Color indicates the Log10 of the following ratios: age (>= 65 / < 65 years), country (Germany / US), ECOG (grades 0-1 / 2-3), LDH (LDH at lymphodepletion chemotherapy: >= 280 / < 280 U/ml), response (CR / no CR at day 180), survival (alive / dead at day 180), early progression (lymphoma progression until day 180 / progression > 180 days or no progression during follow-up) and CRS (grades <=1 / >1). Associations with p-value > 0.05 or with absolute log2 fold change < 1 were set on the heatmap to have a log10 fold change of zero.