Figure 3. Heme- and REV-induced vaso-occlusion in SS Towns mice are inhibited by ADAMTS13.
(A) Heme-induced vaso-occlusion (measured in percentage of stasis) in vivo in SS Towns mice is inhibited by ADAMTS13 (mean ± SD for 1, 2, 3, and 4 hours: Vehicle: 31.8% ± 7.1%, 26.8% ± 2.9%, 24.5% ± 4.5%, 20.8% ± 2.9% vs. ADAMTS13: 6.1% ± 4.7%, 4.9% ± 4.1%, 2.4% ± 2.8%, 2.4% ± 2.8%, p < 0.05 for all time points, n = 4 for each group at each time point). (B) REV-induced vaso-occlusion in vivo in SS Towns mice is inhibited by ADAMTS13 (mean ± SD for 1, 2, 3, and 4 hours: Vehicle: 31.5% ± 5.0%, 25.8% ± 4.1%, 23.4% ± 4.7%, 18.7% ± 4.7% vs. ADAMTS13: 7.2% ± 3.0%, 6.0% ± 2.7%, 3.6% ± 2.4%, 2.3% ± 2.7%, p < 0.05 for all time points, n = 4 for each group at each time point).