Table 2:
Summary of median (most frequent) scores for histologic features stratified by intervention.
| Variable | All Biopsies (N=70) | Confirmed ACR (N=37) | ||||
|---|---|---|---|---|---|---|
| Pretreated (N=26) | Not pretreated (N=44) | P-value | Pretreated (N=17) | Not pretreated (N=20) | P-value | |
| Global Assessment | ||||||
| Mean (SD) | 0.7 (1.1) | 1.2 (1.2) | - | 0.6 (0.8) | 2.0 (1.3) | - |
| Median (IQR) | 0.0 (0.0, 1.0) | 1.0 (0.0, 2.0) | 0.040e | 0.0 (0.0, 1.0) | 2.0 (1.0, 3.0) | <0.001e |
| Portal Inflammation | ||||||
| Mean (SD) | 0.8 (0.7) | 1.2 (0.9) | - | 0.8 (0.5) | 1.8 (0.7) | - |
| Median (IQR) | 1.0 (0.0, 1.0) | 1.0 (1.0, 2.0) | 0.036e | 1.0 (1.0, 1.0) | 2.0 (1.0, 2.0) | <0.001e |
| Endothelialitis | ||||||
| Mean (SD) | 0.4 (0.6) | 0.8 (0.8) | - | 0.3 (0.5) | 1.3 (0.9) | - |
| Median (IQR) | 0.0 (0.0, 1.0) | 1.0 (0.0, 1.0) | 0.053e | 0.0 (0.0, 1.0) | 1.0 (1.0, 2.0) | <0.001e |
| Bile Duct Inflammation/Damage | ||||||
| Mean (SD) | 1.2 (0.9) | 1.1 (0.8) | - | 1.4 (0.7) | 1.6 (0.7) | - |
| Median (IQR) | 1.0 (1.0, 2.0) | 1.0 (1.0, 2.0) | 0.68e | 1.0 (1.0, 2.0) | 2.0 (1.0, 2.0) | 0.32e |
| Rejection Activity Index (RAI) | ||||||
| Mean (SD) | 2.4 (1.8) | 3.2 (2.2) | - | 2.5 (1.3) | 4.7 (2.1) | - |
| Median (IQR) | 2.0 (1.0, 3.0) | 3.0 (1.8, 4.0) | 0.16e | 2.0 (2.0, 3.0) | 4.0 (4.0, 6.0) | <0.001e |
| Ductular Reaction | ||||||
| Mean (SD) | 0.5 (0.6) | 0.4 (0.6) | - | 0.5 (0.6) | 0.4 (0.5) | - |
| Median (IQR) | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 1.00e | 0.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 0.86e |
| Cholestasis | ||||||
| Mean (SD) | 0.5 (0.9) | 0.2 (0.5) | - | 0.8 (1.0) | 0.3 (0.5) | - |
| Median (IQR) | 0.0 (0.0, 1.0) | 0.0 (0.0, 0.0) | 0.15e | 0.0 (0.0, 2.0) | 0.0 (0.0, 1.0) | 0.18e |
| Prominent Eosinophils | ||||||
| No | 24 (92.3%) | 35 (79.5%) | 0.19f | 16 (94.1%) | 13 (65%) | 0.048f |
| Yes | 2 (7.7%) | 9 (20.5%) | - | 1 (5.9%) | 7 (35%) | - |
| Prominent Neutrophils | ||||||
| No | 21 (80.8%) | 37 (84.1%) | 0.75f | 15 (88.2%) | 16 (80%) | 0.67f |
| Yes | 5 (19.2%) | 7 (15.9%) | - | 2 (11.8%) | 4 (20%) | - |
| Prominent Plasma Cells | ||||||
| No | 26 (100%) | 41 (93.2%) | 0.29f | 17 (100%) | 18 (90%) | 0.49f |
| Yes | 0 (0%) | 3 (6.8%) | - | 0 (0%) | 2 (10%) | - |
| Lobular Necrosis | ||||||
| Mean (SD) | 0.7 (0.8) | 0.8 (1.1) | - | 0.8 (0.7) | 1.5 (1.3) | - |
| Median (IQR) | 1.0 (0.0, 1.0) | 0.0 (0.0, 1.0) | 0.88e | 1.0 (0.0, 1.0) | 1.0 (0.0, 3.0) | 0.14e |
| Steatosis | ||||||
| Mean (SD) | 0.4 (0.9) | 0.3 (0.7) | - | 0.2 (0.6) | 0.3 (0.7) | - |
| Median (IQR) | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.0) | 0.82e | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.2) | 0.60e |
e
Exact Wilcoxon rank sum test,
f
Fisher’s exact test