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. 2023 Mar 26;72:101713. doi: 10.1016/j.molmet.2023.101713

Figure 1.

Figure 1

OX-A and 2-AG derived 2-AGP positively correlate and are increased in obese patients: (A) Correlation between the levels of 2-AG and 2-AGP in the ARC of wt mice. n = 16 mice/group; correlation index R = 0.58. (B) Correlation between the levels of 2-AG and 2-AGP in the ARC of ob/ob mice. n = 20 mice/group; correlation index R = 0.61. (C) Correlation between the levels of OX-A and 2-AGP in the ARC of ob/ob mice. n = 20 mice/group; correlation index R = 0.75. Correlations were analyzed using Pearson's correlation coefficient. (D) 2-AG and 2-AGP levels in the ARC of wt or ob/ob mice treated with vehicle, leptin, OX-A, SB334867+OX-A or O7460+OX-A. Data are means ± SEM from n = 6 mice/group, two-way ANOVA with Tukey's multiple comparisons test. Each comparison is represented as follows: ∗ = wt vs ob/ob, # = wt vs wt treated, $ = ob/ob vs ob/ob treated. Overall significance is represented as follow: ∗∗, ##, $$p < 0.01, ∗∗∗, ###, $$$p < 0.001, ∗∗∗∗, ####, $$$$p < 0.0001. (E) Bar graph of OX-A levels in the serum of normal weight (n.w.) and obese subjects. two-tailed Student's t-test, n = 30 per group, 23.27 ± 0.3 pg/ml in n. w and 50.84 ± 1.5 pg/ml in obese. (F) Bar graph of 2-AGP levels in the serum of normal weight (n.w.) and obese human subjects. Two-tailed Student's t-test, n = 30 per group, 259.7 ± 25.41 pmol/mg lipids in n.w. and 593.1 ± 46.07 pmol/mg lipids in obese. (G) Correlation between the levels of OX-A and 2-AGP in the serum of n.w. men (n = 30), R = 0.06, p = 0.17. (H) Correlation between the levels of OX-A and 2-AGP in the serum of obese men (n = 30), R = 0.44.