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. Author manuscript; available in PMC: 2023 Apr 22.
Published in final edited form as: Annu Rev Nutr. 2022 May 18;42:91–113. doi: 10.1146/annurev-nutr-062220-105200

Figure 2. Regulation of hepatic de novo lipogenesis.

Figure 2.

Hepatic DNL gene program is regulated by nutrients, hormonal cues, and pathophysiological signals, which act on several transcription factors and chromatin regulators that culminate in lipogenic gene induction. Carbohydrates such as fructose stimulate gene expression and transcriptional activity of ChREBP, whereas insulin and LXR activation leads to SREBP1c-mediated lipogenic induction. ER stress triggers activation of XBP1 and SREBP1c to regulate lipogenic gene expression.