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. Author manuscript; available in PMC: 2023 Apr 22.
Published in final edited form as: Cell Rep. 2023 Mar 11;42(3):112239. doi: 10.1016/j.celrep.2023.112239

Figure 6. Our working model proposing EC-derived multiple waves of hematopoiesis.

Figure 6.

(A) EC-derived (HSC-independent) and HSC-derived lymphopoiesis show how we can estimate the percentages of each wave.

(B) Multiple waves of hematopoiesis produce MPPs, LPs, B-1a cells, and HSCs during E7.5–E11.5. EC-derived HSPCs are the major cell populations in young animals. While postnatal HSC-derived lymphoid cells replace these embryonic EC-derived blood cells with age, a significant percentage of embryonic EC-derived lymphocytes persist in old mice.