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. 2023 Apr 22;16:81. doi: 10.1186/s13048-023-01156-8

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© The Author(s) 2023, corrected publication 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Downregulation of HSPD1 promotes the proliferation ability of ovarian cancer cells. A Western blotting analysis of HSPD1 expression in SKOV3 and OVCAR3 cells transfected with NC siRNA and HSPD1 siRNA, respectively. B SKOV3 and OVCAR3 cells were transduced with lentiviruses delivering negative control shRNA (sh-NC) or HSPD1 shRNA (sh-HSPD1). Changes in HSPD1 protein expression was measured by western blotting. C Effects of HSPD1 knockdown with siRNA on the proliferation of SKOV3 analyzed by the RTCA assay. D Effects of HSPD1 knockdown with lentivirus shRNA on the proliferation of SKOV3 analyzed by the RTCA assay. E Effects of HSPD1 knockdown with siRNA on the proliferation of OVCAR3 analyzed by the RTCA assay. F Graphical representation of the concentration of glucose in cell culture medium after 72 h cell culture. G Graphical representation of the concentration of lactate in cell culture medium after 72 h cell culture. *P < 0.05, ** P < 0.01 and ***P < 0.001