Table 1.
Table summarising the reannotation of the 69 core proteins identified in 125 genomes of mpox virus.
| Core_Og | Length (aa) | Similar to Uniprot ID | Protein name | Gene | % identity | alignment length | Mismatches | E-Value | Closest crystal structure (% Identity, % Coverage) |
|---|---|---|---|---|---|---|---|---|---|
| OG000 | 344 | P42926 | Serine proteinase inhibitor 2 (Serp-2) (Serpin-2) | SPI-2 | 65.70 | 344 | 117 | 2.7E-149 | 1F0C_A (60.07, 89) |
| OG010 | 492 | Q80DV6 | DNA helicase; Transcript termination protein A18 | A19R | 97.16 | 493 | 13 | 0.0E+00 | 6JDE_A (21.76, 68) |
| OG011 | 1880 | Q8QPZ7 | Poxvirus B22R protein, putative transmembrane glycoprotein | B22R | 86.3 | 1829 | 18 | 0.0E+00 | |
| OG012 | 479 | Q8QMZ9 | Poly(A) polymerase catalytic subunit (EC 2.7.7.19) | PAPL | 99.17 | 479 | 4 | 0.0E+00 | 3ER8_C (98.75, 100) |
| OG013 | 1164 | Q8V4V3 | DNA-dependent RNA polymerase 132 kDa subunit, | Rpo132 | 99.66 | 1164 | 4 | 0.0E+00 | 6RFL_B (98.97, 100) |
| OG014 | 167 | P0DSW8 | truncated interferon antagonist D8 (Host range protein 2) | D8L | 98.67 | 150 | 2 | 1.8E-105 | 5CYW_B (98, 89) |
| OG015 | 155 | P0DSX4 | Protein C6 | C6L | 92.21 | 154 | 12 | 3.0E-101 | |
| OG016 | 316 | P17370 | Protein C4 | C4L | 94.94 | 316 | 16 | 0.0E+00 | 8AG3_C (44.04, 99) |
| OG018 | 273 | P23372 | Protein E8 | E8R | 98.90 | 273 | 3 | 0.0E+00 | |
| OG019 | 665 | P21093 | R1L protein, Protein O1 | O1L | 97.30 | 666 | 17 | 0.0E+00 | |
| OG020 | 152 | P33004 | Protein J1 | J1R | 98.01 | 151 | 3 | 2.6E-104 | |
| OG024 | 206 | P21039 | Protein C5 | C5L | 94.82 | 193 | 10 | 7.8E-131 | 4HXI_A (23.81, 40) |
| OG025 | 43 | P20639 | Protein K3 | K3L | 95.24 | 42 | 2 | 1.6E-23 | 1LUZ_A (92.86, 97) |
| OG026 | 424 | P20537 | Phospholipase-D-like protein K4 | K4L | 98.11 | 424 | 8 | 0.0E+00 | 7E0M_A (24.28, 88) |
| OG027 | 214 | Q6RZR2 | Apoptosis regulator OPG045 | OPG045 | 87.10 | 222 | 21 | 2.9E-134 | 2VTY_A (89.94, 78) |
| OG028 | 486 | P21013 | Kelch repeat protein F3 | F3L | 97.08 | 479 | 14 | 0.0E+00 | 6N3H_A (25.46, 47) |
| OG029 | 319 | O57175 | Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) | OPG048 | 99.06 | 319 | 3 | 0.0E+00 | 1H0N_A (80.94, 99) |
| OG030 | 64 | P24360 | Protein F8 | F8L | 96.92 | 65 | 1 | 2.4E-39 | |
| OG031 | 354 | P21052 | Protein F11 | F11L | 97.18 | 354 | 10 | 0.0E+00 | |
| OG032 | 49 | P0DTM8 | Protein OPG059 | OPG059 | 95.8 | 48 | 2 | 4.4E-40 | |
| OG033 | 101 | P68455 | Phosphoprotein F17 | TF17R | 97.03 | 101 | 3 | 6.6E-70 | |
| OG034 | 153 | P21605 | RNA-binding protein E3 (p25) | E3L | 88.89 | 153 | 17 | 9.7E-96 | 1OYI_A (73.33, 29) |
| OG035 | 259 | P21603 | DNA-directed RNA polymerase 30 kDa polypeptide (EC 2.7.7.6) | RPO30 | 97.68 | 259 | 6 | 0.0E+00 | 6RIC_S (97.68, 100) |
| OG036 | 166 | P68447 | Protein E7 | E7R | 93.98 | 166 | 10 | 2.3E-113 | |
| OG037 | 95 | P21050 | Probable FAD-linked sulfhydryl oxidase E10 (EC 1.8.3.2) | E10R | 98.95 | 95 | 1 | 2.6E-66 | |
| OG038 | 129 | P68448 | viral core protein E11 | E11L | 97.67 | 129 | 3 | 1.6E-91 | 6RFL_Q (97.67, 100) |
| OG039 | 269 | P12923 | ssDNA-binding phosphoprotein, Protein I3 | I3L | 98.51 | 269 | 4 | 0.0E+00 | |
| OG042 | 423 | P20501 | Core protease I7 | I7L | 99.05 | 423 | 4 | 0.0E+00 | |
| OG043 | 591 | P21022 | Metalloendopeptidase G1 | G1L | 98.64 | 590 | 8 | 0.0E+00 | |
| OG044 | 220 | P68456 | Late transcription elongation factor G2, Protein G2 | G2R | 98.64 | 220 | 3 | 5.5E-161 | |
| OG045 | 124 | Q8V507 | Glutaredoxin-2 | EVM065 | 100.00 | 124 | 0 | 4.5E-91 | 2G2Q_A (97.56, 99) |
| OG046 | 340 | P07611 | Myristoylated protein G9, Protein F1 | G9R | 98.53 | 340 | 5 | 0.0E+00 | |
| OG047 | 250 | P0DOT7 | Protein L1; Virion membrane protein M25 | L1R | 99.20 | 250 | 2 | 0.0E+00 | 4U6H_E (98.91, 73) |
| OG048 | 251 | P20981 | core protein VP8 | L4R | 98.81 | 251 | 3 | 0.0E+00 | |
| OG049 | 129 | P68608 | DNA-dependent RNA polymerase 22 kDa subunit rpo22 | Rpo22 | 100.00 | 129 | 0 | 2.7E-92 | 6RFL_E (100, 100) |
| OG051 | 171 | P20495 | Dual specificity protein phosphatase H1 | H1L | 98.83 | 171 | 2 | 1.0E-118 | 2RF6_A (97.66, 100) |
| OG052 | 189 | P0DSY9 | IMV membrane protein, Late protein H2 | H2R | 100.00 | 189 | 0 | 3.7E-145 | |
| OG053 | 324 | P20497 | Envelope protein H3 | H3L | 94.14 | 324 | 19 | 0.0E+00 | 5EJ0_A (93.67, 73) |
| OG054 | 314 | P68697 | DNA topoisomerase 1B | Top1B | 99.36 | 314 | 2 | 0.0E+00 | 2H7G_X (97.77, 100) |
| OG055 | 146 | O57208 | Late protein H7 | H7R | 97.95 | 146 | 3 | 1.7E-105 | 4W60_A (96.58, 100) |
| OG056 | 845 | Q80DX6 | mRNA capping enzyme catalytic 97 kDa subunit | E1R | 99.05 | 845 | 7 | 0.0E+00 | 4CKB_A (98.94, 100) |
| OG057 | 637 | P04308 | Early transcription factor 70 kDa small subunit | VETFS | 99.84 | 637 | 1 | 0.0E+00 | 7AMV_W (99.69, 100) |
| OG058 | 161 | P04310 | DNA-dependent RNA polymerase 18 kDa subunit rpo18 | Rpo18 | 97.52 | 161 | 4 | 5.0E-117 | 6RFL_G (96.89, 100) |
| OG059 | 304 | Q8V4Y0 | Cell Surface Binding Protein, carbonic anhydrase homolog | E8L | 99.67 | 304 | 1 | 0.0E+00 | 4E9O_X (93.89, 86) |
| OG060 | 287 | P20980 | mRNA-capping enzyme 33 kDa small subunit | D12L | 98.96 | 287 | 3 | 0.0E+00 | 2VDW_B (98.61, 100) |
| OG061 | 551 | P68440 | Scaffold protein D13, Rifampicin resistance protein | D13L | 99.09 | 551 | 5 | 0.0E+00 | 6BED_A (99.09, 100) |
| OG062 | 150 | P0DSV3 | Viral late gene transcription factor 2 | VLTF2 | 100.00 | 150 | 0 | 1.3E-110 | |
| OG063 | 644 | P20643 | Virion core protein 4b, p4b | A3L | 99.07 | 644 | 6 | 0.0E+00 | |
| OG064 | 281 | P20983 | 39 kDa core protein | A4L | 95.37 | 281 | 13 | 5.5E-135 | |
| OG065 | 161 | P68610 | DNA-dependent RNA polymerase 19 kDa subunit | Rpo19 | 97.56 | 164 | 1 | 8.1E-94 | 6RFL_F (97.56, 100) |
| OG066 | 891 | P0DOL1 | Virion core protein 4a precursor | A10L | 97.87 | 892 | 18 | 0.0E+00 | |
| OG067 | 318 | P20988 | Protein A11 | A11R | 99.37 | 318 | 2 | 0.0E+00 | |
| OG068 | 190 | P0DOK9 | 25 kDa core protein | A12L | 98.42 | 190 | 15 | 5.7E-99 | |
| OG069 | 196 | P0DOR5 | Virion membrane protein A17 precursor, 23 kDa late protein | A17L | 97.45 | 196 | 4 | 1.3E-96 | |
| OG070 | 77 | P20994 | Zinc finger-like protein, Protein A19 | A19L | 97.40 | 77 | 2 | 3.5E-51 | 2DFY_C (42.86, 54) |
| OG071 | 426 | P68709 | DNA polymerase processivity factor component A20 | A20R | 97.18 | 426 | 12 | 0.0E+00 | 6ZXP_A (96.75, 28) |
| OG072 | 696 | P24759 | A-type inclusion protein A25 (ATI) | A25 | 95.40 | 696 | 28 | 0.0E+00 | |
| OG073 | 146 | Q8V4U9 | Envelope protein A28 homolog (Protein A30) | A30L | 100.00 | 146 | 0 | 5.4E-106 | |
| OG074 | 305 | Q6RZF4 | DNA-directed RNA polymerase 35 kDa subunit (EC 2.7.7.6) | RPO35 | 98.36 | 305 | 5 | 0.0E+00 | 6RFL_C (97.71, 100) |
| OG075 | 181 | P68616 | Protein A33 | A33R | 96.67 | 180 | 6 | 3.0E-130 | 4LQF_A (92.31, 50) |
| OG077 | 227 | P68618 | Protein A36 | A36R | 95.02 | 221 | 9 | 5.9E-134 | |
| OG078 | 213 | P21064 | Protein A41 | A41L | 95.24 | 210 | 8 | 6.5E-147 | 2VGA_A (97.48, 92) |
| OG079 | 346 | P26670 | 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) | SALF7L | 98.84 | 346 | 4 | 0.0E+00 | 6JKG_A (27.02, 69) |
| OG080 | 125 | Q8V4T3 | Cu–Zn superoxide dismutase-like protein | A46R | 100.00 | 125 | 0 | 9.8E-85 | 1P1V_A (30.67, 86) |
| OG081 | 204 | Q80DS7 | Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) | TMK | 98.53 | 204 | 3 | 3.9E-151 | 2V54_A (98.53, 100) |
| OG083 | 334 | P21069 | Protein A51 | A51R | 96.11 | 334 | 13 | 0.0E+00 | |
| OG085 | 176 | P68443 | Protein B6 | B6R | 88.14 | 177 | 16 | 6.9E-109 | |
| OG086 | 282 | P21098 | Pseudokinase B12 | B12 | 97.17 | 283 | 7 | 0.0E+00 | 2LAV_A (32.88, 95) |
| OG089 | 190 | P17365 | Protein C13 (Protein B23R) | C13L | 95.79 | 190 | 8 | 3.5E-131 |