Table 3.
Placental pathologic findings by timing of COVID-19
| Variable | n | Total | First trimester (n=11) | Second trimester (n=35) | Third trimester (n=92) | P value |
|---|---|---|---|---|---|---|
| Placental weight (g), mean (SD) | 137 | 422 (130) | 391 (158) | 383 (133) | 440 (122) | .06 |
| Placental weight of <10th percentile | 134 | 21 (16) | 4 (36) | 4 (12) | 13 (14) | .14 |
| Cord insertion | 135 | .64 | ||||
| Central | 28 (21) | 3 (27) | 5 (15) | 20 (22) | ||
| Eccentric | 101 (75) | 8 (73) | 28 (85) | 65 (71) | ||
| Marginal | 4 (3) | 0 (0) | 0 (0) | 4 (4) | ||
| Velamentous | 2 (2) | 0 (0) | 0 (0) | 2 (2) | ||
| Hypercoil | 138 | 36 (26) | 0 (0) | 9 (26) | 27 (29) | .11 |
| Hypocoil | 138 | 2 (2) | 0 (0) | 1 (3) | 1 (1) | .69 |
| Fetal vascular malperfusion: any feature | 138 | 16 (12) | 2 (18) | 5 (14) | 9 (10) | .60 |
| Maternal vascular malperfusion | 138 | .44 | ||||
| None | 88 (64) | 6 (55) | 19 (54) | 63 (69) | ||
| Mild | 46 (33) | 5 (46) | 14 (40) | 27 (29) | ||
| Severe | 4 (3) | 0 (0) | 2 (6) | 2 (2) | ||
| Any feature | 50 (36) | 5 (46) | 16 (46) | 29 (32) | .27 | |
| Evidence of placental hypoxia: any feature | 138 | 40 (29) | 4 (36) | 7 (20) | 29 (32) | .38 |
| Evidence of placental response to infection: any feature | 138 | 38 (28) | 5 (46) | 14 (40) | 19 (21) | .04 |
| Evidence of placental inflammation: any feature | 138 | 21 (15) | 1 (9) | 6 (17) | 14 (15) | .81 |
| No placental lesion | 138 | 32 (23) | 1 (9) | 8 (23) | 23 (25) | .50 |
Data are presented as number (percentage), unless otherwise indicated. Complete lists of features for each category are listed in Supplemental Tables 2 and 3.
SD, standard deviation.
Corbetta-Rastelli. COVID-19 placental pathology. Am J Obstet Gynecol MFM 2023.