Table 4.
Placental pathologic findings by severity of COVID-19
| Variable | n | Total | Asymptomatic (n=31) | Mild or moderate (n=93) | Severe or critical (n=14) | P value |
|---|---|---|---|---|---|---|
| Placental weight (g), mean (SD) | 137 | 422 (130) | 455 (141) | 429 (117) | 299 (127) | .0005a |
| Placental weight of <10th percentile | 134 | 21 (16) | 6 (19) | 13 (14) | 2 (15) | .81 |
| Cord insertion | 135 | .50 | ||||
| Central | 28 (21) | 4 (13) | 22 (24) | 2 (17) | ||
| Eccentric | 101 (75) | 27 (87) | 65 (71) | 9 (75) | ||
| Marginal | 4 (3) | 0 (0) | 3 (3) | 1 (8) | ||
| Velamentous | 2 (2) | 0 (0) | 2 (2) | 0 (0) | ||
| Hypercoil | 138 | 36 (26) | 14 (45) | 21 (23) | 1 (7) | .01 |
| Hypocoil | 138 | 2 (2) | 0 (0) | 2 (2) | 0 (0) | .61 |
| Fetal vascular malperfusion: any feature | 138 | 16 (12) | 3 (10) | 12 (13) | 1 (7) | .76 |
| Maternal vascular malperfusion | 138 | .55 | ||||
| None | 88 (64) | 22 (71) | 59 (63) | 7 (50) | ||
| Mild | 46 (33) | 9 (29) | 31 (33) | 6 (43) | ||
| Severe | 4 (3) | 0 (0) | 3 (3) | 1 (7) | ||
| Any feature | 50 (36) | 9 (29) | 34 (37) | 7 (50) | .40 | |
| Evidence of placental hypoxia: any feature | 138 | 40 (29) | 10 (32) | 27 (29) | 3 (21) | .76 |
| Evidence of placental response to infection: any feature | 138 | 38 (28) | 7 (23) | 30 (32) | 1 (7) | .11 |
| Evidence of placental inflammation: any feature | 138 | 21 (15) | 4 (13) | 15 (16) | 2 (14) | .91 |
| No placental lesion | 138 | 32 (23) | 7 (23) | 21 (23) | 4 (29) | .88 |
Data are presented as number (percentage), unless otherwise indicated. Complete lists of features for each category are listed in Supplemental Tables 2 and 4.
SD, standard deviation.
a
P<.01.
Corbetta-Rastelli. COVID-19 placental pathology. Am J Obstet Gynecol MFM 2023.