Table VII.
Primary outcome measures for outpatient AOM visits stratified by age
| Age | Antibiotic | Treatment failure |
Recurrence |
||||||
|---|---|---|---|---|---|---|---|---|---|
| N (, 95 CI) | OR (95 CI) | aOR (95 CI) | P | N (, 95 CI) | OR (95 CI) | aOR (95 CI) | P | ||
| 6 m to <2 y | Amoxicillin | 724 (0.54, 0.50, 0.58) | Ref | – | – | 2090 (1.55, 1.48, 1.62) | Ref | – | – |
| Amoxicillin-clavulanate | 2652 (6.54, 6.30, 6.79) | 12.98 (11.94, 14.10) | 13.06 (11.96, 14.26) | <.0001 | 3719 (9.18, 8.90, 9.46) | 6.42 (6.08, 6.78) | 6.59 (6.21, 6.99) | <.0001 | |
| Cefdinir | 3368 (5.77, 5.58, 5.96) | 11.34 (10.46, 12.30) | 11.57 (10.61, 12.61) | <.0001 | 5008 (8.58, 8.35, 8.80) | 5.96 (5.66, 6.28) | 6.12 (5.79, 6.48) | <.0001 | |
| Azithromycin | 1329 (7.40, 7.02, 7.78) | 14.81 (13.51, 16.24) | 15.36 (13.92, 16.94) | <.0001 | 1412 (7.86, 7.47, 8.26) | 5.42 (5.06, 5.81) | 5.60 (5.19, 6.04) | <.0001 | |
| Total | 8073 (3.21, 3.14, 3.28) | – | – | – | 12 229 (4.86, 4.77, 4.94) | – | – | – | |
| 2-5 y | Amoxicillin | 1005 (0.45, 0.42, 0.48) | Ref | – | – | 3019 (1.35, 1.30, 1.40) | Ref | – | – |
| Amoxicillin-clavulanate | 2466 (4.73 4.55, 4.91) | 10.99 (10.21, 11.84) | 10.81 (9.98, 11.71) | <.0001 | 1966 (3.98, 3.81, 4.15) | 5.06 (4.81, 5.32) | 4.94 (4.68, 5.22) | <.0001 | |
| Cefdinir | 3230 (3.88, 3.75, 4.01) | 8.93 (8.31, 9.59) | 8.86 (8.21, 9.57) | <.0001 | 4779 (5.74, 5.58, 5.89) | 4.44 (4.24, 4.65) | 4.42 (4.20, 4.65) | <.0001 | |
| Azithromycin | 1576 (4.54, 4.32, 4.76) | 10.53 (9.72, 11.41) | 10.82 (9.93, 11.79) | <.0001 | 1951 (5.62, 5.38, 5.87) | 4.35 (4.11, 4.61) | 4.36 (4.09, 4.65) | <.0001 | |
| Total | 8277 (2.10, 2.06, 2.15) | – | – | – | 13 123 (3.33, 3.28, 3.39) | – | – | – | |
| 6-12 y | Amoxicillin | 862 (0.37, 0.34, 0.39) | Ref | – | – | 2658 (1.13, 1.08, 1.17) | Ref | – | – |
| Amoxicillin-clavulanate | 1859 (3.76, 3.60, 3.93) | 10.67 (9.84, 11.58) | 10.64 (9.77, 11.60) | <.0001 | 1966 (3.98, 3.81, 4.15) | 3.64 (3.43, 3.86) | 3.60 (3.38, 3.84) | <.0001 | |
| Cefdinir | 2362 (3.15, 3.02, 3.27) | 8.87 (8.21, 9.60) | 8.94 (8.23, 9.72) | <.0001 | 2879 (3.84, 3.70, 3.98) | 3.51 (3.32, 3.70) | 3.53 (3.33, 3.74) | <.0001 | |
| Azithromycin | 1596 (3.53, 3.36, 3.70) | 9.99 (9.19, 10.86) | 10.32 (9.45, 11.28) | <.0001 | 1685 (3.73, 3.55, 3.90) | 3.40 (3.20, 3.62) | 3.45 (3.23, 3.69) | <.0001 | |
| Total | 6679 (1.65, 1.61, 1.69) | – | – | – | 9188 (2.26, 2.22, 2.31) | – | – | ||