Fig. 1.

Enhanced mGluR-LTD in the adolescent Fmr1 KO hippocampus. A Induction of mGluR-LTD by bath application of DHPG (100 μM, 10 min) at age p28-p35 in WT and Fmr1 KO mice. n = 56 channels recorded from 8 slices of five WT mice, n = 63 channels recorded from 9 slices of six KO mice; ** p < 0.01 versus WT mice, unpaired two-tailed Student’s t test. B DHPG induced mGluR-LTD at age p8-p15 in WT and Fmr1 KO mice. n = 58 channels recorded from 8 slices of five WT mice, n = 53 channels recorded from 9 slices of five KO mice, unpaired two-tailed Student’s t test. C NMDAR-LTD was induced by LFS (900 pulses at 1 Hz, 15 min) at age p28-p35 in WT and Fmr1 KO mice. n = 61 channels recorded from 9 slices of five WT mice, n = 73 channels recorded from 9 slices of six KO mice, unpaired two-tailed Student’s t test. D LFS induced NMDAR-LTD at age p8-p15 in WT and Fmr1 KO mice. n = 55 channels recorded from 7 slices of four WT mice, n = 69 channels recorded from 9 slices of five KO mice, unpaired two-tailed Student’s t test. Top, representative traces of 64 channels recorded at baseline (black) and 1 h after stimulation (colors). Calibration bars: 0.2 mV, 50 ms. Bottom left, normalized fEPSP slope (% baseline) of LTD from total active channels. Bottom right, summary graph of the final average fEPSP slope during the last 30 min