Fig. 8.

Extracellular Glu concentration changes in dialysate samples during ischemia/reperfusion in the cerebral cortex. Changes of Glu concentrations are expressed as % of preischemic Glu concentration. Data are presented as mean ± SEM (n = 8). Two-way repeated measures ANOVA was conducted, followed by Sidak post hoc test (*p < 0.05, **p < 0.01, ***p < 0.001 for comparisons vs SHAM; #p < 0.05, ##p < 0.01 for comparisons vs MCAO). Microdialysates were collected during the following periods: preischemia (− 60 to 0 min); ischemia (0–90 min), reperfusion (90–180 min), and next in the experimental setup involving freely-moving animals at three 30-min intervals 24 h and 3 days after reperfusion. CSB6B was administered intraventricularly at 2 h before MCAO surgery or SHAM procedure