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. 2023 Apr 22;6:445. doi: 10.1038/s42003-023-04821-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Volcano plot depicting differential RNA polymerase II binding following NF-κB/p52 activation and those bound by ETS1. b DNA binding heatmap of the significantly upregulated RNA polymerase II sites following NF-κB/p52 activation and the effect of NFKB2 and ETS1 KD. c Heatmap depicting ETS1-dependent, significantly upregulated genes following NF-κB/p52 activation. d Bar chart depicting enriched GO terms from significantly upregulated ETS1 and p52-dependent differentially expressed genes (DEGs) as well as ETS1-dependent and p52-independent DEGs.