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. 2023 Apr 22;6:445. doi: 10.1038/s42003-023-04821-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Proliferation assay plot depicts the average number of cells counted relative to 0 h (mean ± s.d) in U-87 MG and U-251 MG NFKB2 and ETS1 KD cells with and without TWEAK-induced NF-κB/p52 activation. The data shown represent n = 3 biological replicates. b Transwell invasion assay was performed in U-87 MG and U-251 MG ETS1 KD cells with and without TWEAK treatment. Representative images from n = 3 biological replicates are shown. Scale bars: 400 µm. Representative plots depict the average number of invaded cells (mean ± s.d) across five fields. Representative plots depicting the average tumour volume (mean ± s.d) of U-87 MG cells injected into mice that express either CRISPR control, NFKB2 KD or ETS1 KD and overexpression control or TWEAK c over 35 days and d on day 35. The data shown represent n = 4 mice. Two-way ANOVA was used for all statistical analyses where *P < 0.05; **P < 0.01; ***P < 0.001.