Table 3.
Treatment characteristics in six-time intervals
|
Parameter
|
2015-2016
|
2017
|
2018
|
2019
|
2020
|
2021
|
| Number of patients | 1199 | 827 | 573 | 438 | 199 | 341 |
| History of previous therapy | ||||||
| Treatment-naïve | 543 (45.3) | 532 (64.3) | 470 (82.0) | 385 (87.9) | 171 (86) | 318 (93.2) |
| Nonresponder | 290 (24.2) | 103 (12.5) | 23 (4.0) | 7 (1.6) | 6 (3) | 11 (3.2) |
| Relapser | 173 (14.4) | 72 (8.7) | 49 (8.5) | 35 (8) | 17 (8.5) | 6 (1.8) |
| Discontinuation due to safety reason | 71 (5.9) | 40 (4.8) | 14 (2.5) | 4 (0.9) | 1 (0.5) | 3 (0.9) |
| Unknown type of response | 120 (10.0) | 76 (9.2) | 14 (2.5) | 7 (1.6) | 2 (1) | 3 (0.9) |
| No data | 2 (0.2) | 4 (0.5) | 3 (0.5) | 0 | 2 (1) | 0 |
| Number of patients with treatment failure | n = 654 | n = 291 | n = 100 | n = 53 | n = 26 | n = 23 |
| IFN ± RBV | 64 (9.8) | 36 (12.4) | 2 (2) | 0 | 0 | 0 |
| PegIFN ± RBV | 390 (59.6) | 197 (67.7) | 48 (48) | 14 (26.4) | 9 (34.6) | 9 (39.1) |
| PegIFN + RBV + DAA | 196 (30) | 47 (16.1) | 10 (10) | 3 (5.7) | 0 | 0 |
| IFN-free | 4 (0.6) | 11 (3.8) | 39 (39) | 35 (66) | 17 (65.4) | 14 (60.9) |
| No data | 0 | 0 | 1 (1) | 1 (1.9) | 0 | 0 |
| Current treatment regimen | ||||||
| Genotype-specific treatment regimens | ||||||
| ASV + DCV | 42 (3.5) | 13 (1.6) | 0 | 0 | 0 | 0 |
| LDV/(SOF ± RBV) | 350 (29.2) | 283 (34.2) | 154 (26.9) | 16 (3.7) | 5 (2.5) | 4 (1.2) |
| OBV/PTV/(r ± DSV ± RBV) | 745 (62.1) | 327 (39.5) | 32 (5.6) | 0 | 0 | 1 (0.3) |
| GZR/(EBR ± RBV) | 0 | 97 (11.7) | 205 (35.8) | 76 (17.3) | 16 (8) | 15 (4.4) |
| Other | 62 (5.2) | 104 (12.6) | 19 (3.3) | 0 | 0 | 0 |
| SOF ± SMV ± DCV ± RBV, SMV ± DCV ± RBV | ||||||
| Pangenotypic regimens | ||||||
| GLE/PIB | 0 | 1 (0.1) | 59 (10.3) | 178 (40.6) | 99 (49.8) | 117 (34.3) |
| GLE/(PIB + SOF + RBV) | 0 | 0 | 0 | 2 (0.5) | 0 | 0 |
| SOF/(VEL ± RBV) | 0 | 2 (0.3) | 104 (18.1) | 166 (37.9) | 79 (39.7) | 195 (57.2) |
| VOX/VEL/SOF | 0 | 0 | 0 | 0 | 0 | 9 (2.6) |
| Current-RBV-containing therapies | 855 (71.3) | 360 (43.5) | 163 (28.4) | 44 (10) | 12 (6) | 23 (6.7) |
IFN: Interferon; RBV: Ribavirin; PegIFN: Pegylated interferon; DAA: Direct-acting antivirals; ASV: Asunaprevir; DCV: Daclatasvir; LDV: Ledipasvir; SOF: Sofosbuvir; OBV: Ombitasvir; PTV/r: Paritaprevir; DSV: Dasabuvir; GZR: Grazoprevir; EBR: Elbasvir; SMV: Simeprevir; GLE: Glecaprevir; PIB: Pibrentasvir; VEL: Velpatasvir; VOX: Voxilaprevir.