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. Author manuscript; available in PMC: 2023 Jun 17.
Published in final edited form as: Org Lett. 2022 Jun 2;24(23):4176–4181. doi: 10.1021/acs.orglett.2c01409

Scheme 2. Scope of Hydrazone in the Alkylation Reactiona.

Scheme 2.

aAt a 0.3 mmol scale. bXantphos (15 mol %) was used instead of PPh3. cHexamethylphosphoramide (HMPA, 0.2 M) was used as a solvent (if X = Br). dPd(PPh3)4 (5 mol %) was used instead of Pd(OAc)2/PPh3. eA 1.5 equiv of redox-active ester used. fA 2 mmol scale yield. gA 1 equiv of tertiary bromide and 1.2 equiv of compound 1.