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. Author manuscript; available in PMC: 2023 Apr 23.
Published in final edited form as: Transplant Cell Ther. 2020 Dec 16;27(4):308.e1–308.e8. doi: 10.1016/j.jtct.2020.12.010

Table 1.

Study Definition for TA-TMA

Criteria 1: Must have 2 or more laboratory criteria for MAHA within 7 days or single MAHA with a haptoglobin checked within 7 days (suspicion for hemolysis)
Red cell fragmentation and Slight, moderate, or marked schistocytes (>2/HPF)
Lactate dehydrogenase and ≧2 times the upper limit of normal
Thrombocytopenia and Platelets ≦50k or ≦100k if transfused or ≧50% drop
Anemia and Hemoglobin or hematocrit ≦lower limit of normal
Timing All 4 laboratory values must occur concurrently within 24 hours
Criteria 2. Does not have other obvious causes for TMA through clinical chart review
Not isolated MAHA and must be persistent more than twice
Not immune hemolysis and negative direct Coombs test (DAT) if checked
Not severe coagulopathy and does not meet ISTH criteria for DIC
Not disease relapse no documented pretransplantation disease relapse