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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Cell Signal. 2023 Jan 21;105:110607. doi: 10.1016/j.cellsig.2023.110607

Figure 4. TACE inhibitor KP-457 reduces TNF proliferation.

Figure 4.

RBL-2H3 cells sensitized with anti-TNP IgE were challenge with TNP-BSA along with specified amounts of KP-457 or solvent (DMSO). At 1 h time point, β-hexosaminidase secretion (A), released TNF (recovered from the supernatant) (B) and total TNF protein level (C) were measured and the values were normalized against that of the solvent control (lane 2). Averages and standard deviations from at least 5 biological repeats are presented. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001