. 2023 May 1;27(3):221–230. doi: 10.4196/kjpp.2023.27.3.221

Table 1.

Influence of canagliflozin and puerarin on lipid metabolic parameters in diabetes mice at the end of treatment (22 weeks of age)

Parameter	Control	Diabetes	Can	Pue (mg/kg)				Can + Pue (mg/kg of Pue)
Parameter	Control	Diabetes	Can	4	10	40	100	4	10	40	100
TC (mM)	5.15 ± 0.29	7.34 ± 0.34^##	6.80 ± 0.15^##^**	6.88 ± 0.21^##^**	6.46 ± 0.26^##^**^{^}	6.14 ± 0.23^##^**^{^^}	5.47 ± 0.20^#^**^{^^}	6.54 ± 0.27^##^**	6.13 ± 0.22^##^**^{^^}	5.25 ± 0.29^**^{^^}	5.18 ± 0.25^**^{^^}
LDL-C (mM)	2.57 ± 0.15	3.97 ± 0.08^##	3.54 ± 0.12^##^**	3.75 ± 0.07^##^*^{^}	3.69 ± 0.08^##^**	3.12 ± 0.10^##^**^{^^}	3.02 ± 0.12^##^**^{^^}	3.42 ± 0.09^##^**	3.22 ± 0.12^##^**^{^^}	2.58 ± 0.22^**^{^^}	2.67 ± 0.29^**^{^^}
HDL-C (mM)	2.90 ± 0.08	1.97 ± 0.14^##	2.22 ± 0.11^##^**	2.43 ± 0.19^##^**^{^^}	2.49 ± 0.13^##^**^{^^}	2.66 ± 0.08^##^**^{^^}	2.53 ± 0.08^##^**^{^^}	2.56 ± 0.18^##^**^{^^}	2.57 ± 0.17^##^**^{^^}	2.83 ± 0.08^**^{^^}	2.86 ± 0.12^**^{^^}
TG (mM)	2.33 ± 0.12	3.23 ± 0.04^##	3.02 ± 0.08^##^*	3.03 ± 0.14^##^*	2.61 ± 0.11^##^**^{^^}	2.89 ± 0.08^##^**	2.19 ± 0.10^**^{^^}	2.84 ± 0.16^##^**^{^}	2.48 ± 0.14^**^{^^}	2.36 ± 0.17^**^{^^}	2.18 ± 0.26^**^{^^}

Data are presented as the mean ± SD (n = 6). TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; TG, triglyceride. ^#p < 0.05, ^##p < 0.01 vs. Control; *p < 0.05, **p < 0.01 vs. Diabetes; ^{^}p < 0.05, ^{^^}p < 0.01 vs. Can.