Table 1.
Summary of published studies on oral fexofenadine used in the analysis
| Study | Number of participants |
Fexofenadine collection timepoints (h) |
Study intervention a |
|---|---|---|---|
| 120 | 10 (4 females) | 0, 0.5, 1, 2, 3, 4, 5, 6, 8, 12 | Baseline |
| 222 | 18 (9 females) | 0, 1, 1.5, 2, 3, 4, 5, 6, 8, 10, 12, 24, 36, 48, 72 | Baseline, baseline plus grapefruit juice |
| 319 | 12 (4 females) | 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 24 | Baseline, baseline plus Panax ginseng |
| 421 | 13 (5 females) | 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 24 | Baseline, baseline plus Echinacea Purpurea |
a
Healthy, adult participants received 120 mg of fexofenadine alone (baseline) or in combination with grapefruit juice (240 mL taken with fexofenadine once), Panax ginseng (500 mg twice daily for 28 days), or Echinacea purpurea (500 mg three times a day for 4 weeks).