Table 2.

Fexofenadine population pharmacokinetic parameter estimates from the final model and parameter estimates from bootstrap validation

Parameter	Final Estimate	Standard error of estimate	Bootstrap Estimate (median and 95% CI)*
V2/F (L)	27.3	10.8	28.8 (17.7–47.8)
CL/F (L/h)	69.7	3.65	69.8 (62.3–78.6)
Ka (h−1)	0.282	0.0192	0.282 (0.241–0.332)
V3/F (L)	269	28.6	264 (214–324)
Q/F (L/h)	19.7	2.00	19.5 (15.6–24.9)
D1 (h)	1.59	0.106	1.59 (1.17–2.12)
GFJ on F	0.748	0.0448	0.746 (0.668–0.834)
Between Subject Variability
V2/F	151%	0.234	147% (111–191)
CL/F	40%	0.0382	40% (32–47)
Ka	33%	0.0342	32% (0.244–0.389)
V3/F	47%	0.0919	44% (22–61)
Residual Variability
Proportional Error	38.4%	0.0153	38.2% (35–42)
Additive Error	0.48 ng/mL	0.146	0.46 ng/mL (0.002–1.72)

^*Bootstrap converged 84% of the time.

$\frac{CL}{F}\left(\frac{L}{hr}\right)=69.7$/(0.748 with coadministration of grapefruit juice)