Table 3.

Single- and two-time point-limited sampling models to estimate fexofenadine exposure

Timepoint(s) to estimate AUC	R2	%MPE	%MAE	%RMSE
1-h	0.08	9%	27%	37%
2-h	0.23	18%	26%	35%
4-h	0.73	−2%	15%	20%
5-h	0.72	−8%	16%	21%
8-h	0.60	9%	18%	26%
1 plus 8 h	0.80	10%	13%	19%
2 plus 4 h	0.72	0.05%	15%	20%
2 plus 5 h	0.78	−2%	13%	18%
2 plus 8 h	0.81	21%	14%	21%
4 plus 8 h	0.77	−1%	13%	18%
Acceptable criteria	≥ 0.9	−5% to +5%	≤ 10%	≤ 15%

Abbreviations: AUC, area under the plasma concentration versus time curve; R², Coefficient of Determination; %MAE, relative percent mean absolute error; %MPE, relative percent mean prediction error; %RMSE, relative percent root mean squared error.

Bold values denote that the model is within acceptable limits.