(A) Average number of pups born per delivery. N=4 males each for Pdcl2+/− and Pdcl2−/−, mated with two females per male. ***P<0.001, Student’s t-test.
(B) Testis to body weight ratio. N=3 males for wild-type and N=4 Pdcl2−/−. **P<0.01, Student’s t-test.
(C) PAS and hematoxylin staining of testicular sections from wild-type and Pdcl2−/− mice. Scale bars: 50 μm.
(D) Sperm motility results using computer-assisted sperm analysis (CASA). ***P<0.001, Student’s t-test.
(E) Observation of the acrosome and flagella using EGFP expressed under the Acrosin promoter and mitochondria-targeted DsRed2 in the principal piece in wild-type and Pdcl2−/− sperm. Scale bars: 10 μm.