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. 2023 Apr 10;14:1128133. doi: 10.3389/fgene.2023.1128133

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Copyright © 2023 Rajcsanyi, Hoffmann, Ghosh, Matrisch-Dinkler, Zheng, Peters, Sun, Dong, Noé, Wolfrum, Herpertz-Dahlmann, Seitz, de Zwaan, Herzog, Ehrlich, Zipfel, Giel, Egberts, Burghardt, Föcker, Tsai, Müller, Blüher, Hebebrand, Hirtz and Hinney.

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Z-scores for BMI-associated SNPs located in CKB and the 500 kb adjacent region. Here, the absolute z-scores were plotted against the chromosomal position of each SNP (GRCh37). After the extraction of the sex-stratified BMI GWAS data (Pulit et al., 2019), ambiguous SNPs were removed. Subsequently, the effect directions were harmonized, and the z-scores were calculated for each genome-wide and thus BMI-associated SNP within the region of CKB (black) and its 500 kb surrounding region (gray). A SNP is considered sex-dimorphic if |z-score| ≥ 3.