TABLE 2.

Phenotypic data of the screening and confirmation study groups. The initial screening samples subjected to the mutation screen consisted of 192 children and adolescents with severe obesity or AN (acute or recovered) and 192 healthy-lean controls (Hinney et al., 2007; Scherag et al., 2010; Boraska et al., 2012; Watson et al., 2019). Additional genotyping was performed in an independent confirmation study group based on family-based samples consisting of the child or adolescent with severe obesity and both biological parents (trios) as well as additional individuals with severe obesity or normal weight previously recruited for a case-control GWAS for obesity (Hinney et al., 2007; Scherag et al., 2010). Phenotypic data regarding BMI and age were missing for 16 parents. n: number of samples. SD: standard deviation.

Sample	Status		N	% Female	Age in years: Mean (SD)	BMI in kg/m2: Mean (SD)	BMI-SDSLMS: Mean (SD)
Screening samples	Children and adolescents with severe obesity		192	56	13.88 (2.50)	32.36 (6.04)	2.60 (0.54)
	Patients with AN	total	192	100	21.85 (10.60)	16.38 (3.12)	−2.61 (1.86)
		acute	141	100	18.44 (8.70)	14.90 (1.85)	−3.20 (1.79)
		recovered	51	100	31.28 (9.68)	20.47 (2.09)	−0.98 (0.79)
	Controls		192	45	25.55 (3.91)	18.38 (1.10)	−2.21 (0.46)
Confirmation samples	Family-based samples	Children and adolescents with obesity	781	55	13.45 (3.11)	32.15 (5.92)	2.65 (0.53)
		Parents	1,562	50	42.60 (6.00)	30.38 (6.29)	0.77 (1.12)
	Samples from an obesity GWAS	Children and adolescents with obesity	320	58	14.60 (4.24)	33.77 (7.00)	2.69 (0.56)
		Controls	253	74	26.40 (6.84)	17.85 (1.11)	−2.32 (0.66)