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. 2023 Apr 10;14:1175970. doi: 10.3389/fphar.2023.1175970

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Copyright © 2023 Hou, Xu, Cao, Tian, Wang, Zhu, Zhang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental design and behavioral analysis. (A) Experimental design for medication treatment in C57BL/6 mice and behavioral analysis; (B) Open field task: a. total movement distance, b. activity time; (C) Morris water maze: a. latency to platform in the 5-day training phase, b. movement tracking in the positioning navigation phase, c. movement distance in target quadrant, d. number of platform crossings. (Compared with the Nor group: ^# p < 0.05, ^## p < 0.01; compared with the Aging group: ^* p < 0.05, ^** p < 0.01, n = 8).