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. 2023 Apr 10;14:1148190. doi: 10.3389/fphar.2023.1148190

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Copyright © 2023 von Mücke-Heim, Martin, Uhr, Ries and Deussing.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microglia shape descriptors after hP2X7R-targeting treatments (i.e., BzATP, LPS + BzATP, JNJ-47965567, A-804598). Graphs show between-genotype and treatment comparisons of (A) cell perimeter, (B,C) roundness and circularity, (D) aspect ratio, (E) solidity, and (F) the complexity index. Shape descriptor values were corrected per group by the respective untreated within-genotype control well means. The hP2X7R-proficient group (CTRL) is displayed in white, the hP2X7R-knockout group (KO) is shown is grey. Data are expressed as mean + S.E.M, KW with Dunn’s test, *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001, n = 8–11 mice per group (except: A-804598 in CTRL group, n = 5 mice). Cells per group (CTRL A-804598): perimeter = 831–2,131 (666); roundness = 815–2039 (645); circularity = 836–2,132 (666); aspect ratio = 785–1997 (616); solidity = 777–2072 (657); complexity = 800–2093 (651).