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. 2023 Apr 24;38(11):1125–1128. doi: 10.1007/s10654-023-01006-3

Table 1.

Estimated number of preventable COVID-19-associated deaths among unvaccinated adults (aged ≥ 18 years), May 30, 2021–September 3, 2022

30 jurisdictionsa US
Number of individuals aged ≥ 18 years (mean) 159,862,404b 233,656,270c
Estimated number of preventable COVID-19-associated deaths among unvaccinated adults (aged ≥ 18 years), May 30, 2021–September 3, 2022

158,000d

(146,000–170,000)

232,000e

(214,000–250,000)

The period of May 30–December 4, 2021

97,600

(91,000–104,000)

144,000

(134,000–154,000)

The period of December 5, 2021–April 30, 2022

52,300

(48,500–56,200)

76,300

(70,700–81,900)

The period of May 1–September 3, 2022

7,850

(6,150–9,540)

11,400

(8,910–13,800)

Age distribution of preventable deaths (%), in years
 18–29 1.38 1.37
 30–49 11.9 11.8
 50–64 27.3 27.7
 65–79 36.5 36.1
 80+ 22.9 23.0

aThe 30 jurisdictions included: Alabama, Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Idaho, Indiana, Kansas, Kentucky, Louisiana, Massachusetts, Michigan, Minnesota, Nebraska, New Jersey, New Mexico, New York City, North Carolina, Philadelphia, Rhode Island, South Dakota, Tennessee, Texas, Utah, Washington, and West Virginia

bPartially vaccinated individuals were excluded from the data set for the 30 jurisdictions; only those vaccinated with at least a primary series and unvaccinated individuals counted toward the total for each week, and this table reports the mean across the study period

cFrom the US 2019 population estimates by single year of age after excluding persons partially vaccinated

dCOVID-19-associated death outcome was defined as a death that occurred within 30 days of a laboratory-confirmed positive test and/or was caused by COVID-19

eThis estimate was extrapolated based on the United States 2019 population estimates for persons aged ≥ 18 years, under the assumption that the rest of the country had the same proportion of unvaccinated persons as the 30 participating jurisdictions after excluding persons partially vaccinated (proportion partially vaccinated was also assumed to be the same between the 30 jurisdictions and the rest of the country) (Appendix I)