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Co-localization of YY1 and Msx2 in E10 and E12 mouse embryos. Whole mount in situ hybridization detected gene expression for YY1 and Msx2 in E10 (A and B) and E12 (C and D) mouse embryos, respectively. Expression of both genes was observed in the developing first and second branchial arches (arrows) and limb buds (arrowheads) at the E10 stage, and persisted in the distal limb bud at the E12 stage (arrows). Low level of YY1 expression was noted throughout the E10 embryo.
