Table 1.
Characteristics of derivation (Massachusetts General Hospital) and validation (Brigham and Women’s Hospital) samples
| Derivation sample (MGH N = 34,258) | Validation sample (BWH N = 16,451) | |
|---|---|---|
| Age, y | 63.2 ± 15.3 | 62.7 ± 15.0 |
| Female sex | 13,622 (39.8) | 7309 (44.4) |
| Height, in | 66.8 ± 7.8 | 66.8 ± 11.1 |
| Weight, lb | 183.4 ± 50.1 | 184.3 ± 48.6 |
| Systolic blood pressure, mm Hg | 128.7 ± 18.5 | 132.0 ± 19.8 |
| Diastolic blood pressure, mm Hg | 74.4 ± 10.9 | 75.7 ± 12.5 |
| Diabetes | 6512 (19.0) | 3665 (22.3) |
| Coronary artery disease | 17,212 (50.2) | 8052 (48.9) |
| Myocardial infarction | 7444 (21.7) | 5198 (31.6) |
| Valvular disease | 5791 (16.9) | 3053 (18.6) |
| Atrial fibrillation | 10,615 (31.0) | 5132 (31.2) |
| Obesity | 2415 (7.0) | 1361 (8.3) |
| Chronic kidney disease | 5594 (16.3) | 2959 (18.0) |
| Hypertension | 24,926 (72.8) | 11,342 (68.9) |
| Antihypertensive medication | 26,641 (77.8) | 13,871 (84.3) |
| Ethnicity | ||
| White | 29,888 (87.2) | 13,315 (80.9) |
| Black | 1125 (3.3) | 1239 (7.5) |
| Asian | 920 (2.7) | 348 (2.1) |
| Hispanic | 612 (1.8) | 595 (3.6) |
| Other | 971 (2.8) | 482 (2.9) |
| Mixed | 1 (0.0) | 1 (0.0) |
| Unknown | 745 (2.2) | 472 (2.9) |
| Clinical ECG LVH rules | ||
| aVL | 3154 (9.2) | 1397 (8.5) |
| Sokolow-Lyon | 1179 (3.4) | 562 (3.4) |
| Cornell | 2763 (8.1) | 1278 (7.8) |
| Any† | 5463 (15.9) | 2459 (14.9) |
Data are displayed as mean ± standard deviation or n (%) unless otherwise noted.
BWH = Brigham and Women’s Hospital; ECG = electrocardiogram; LVH = left ventricular hypertrophy; MGH = Massachusetts General Hospital.
†
Clinical ECG LVH criteria “Any” category aggregates aVL, Sokolow-Lyon, and Cornell criteria.