Figure 4.

Interaction between polygenic risk and de novo variants (DNV). (A) Distribution difference of polygenic risk score (PRS) between probands with and without types of DNV. (B) Distribution difference of PRS between probands with and without dDNVs-ASDG. All polygenic scores were z-score scaled, and pairwise comparisons were performed via t-tests. **p < 0.01, ***p < 0.001. dnSyn, de novo synonymous variants; dnTmis, de novo tolerant missense variants (REVE <0.7); dnDmis, de novo deleterious missense variants (REVE ≥0.7); dnLoF, de novo loss-of-function variants; CNV, copy number variants; dDNV, damaging DNV; dDNVs-ASDG, dDNVs in ASD risk genes.