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. 2023 Apr;193(4):474–492. doi: 10.1016/j.ajpath.2022.12.009

Figure 5.

Figure 5

Cardiac troponin T and echocardiographic measurements in myocardial infarction mouse model. A–G: Histograms showing cardiac troponin T (A), as well as echocardiographic measurement data after acute myocardial infarction (AMI): ejection fraction (B), fractional shortening (C), global longitudinal strain (D), left ventricular (LV) end-diastolic diameter (E), LV end-systolic diameter (F), and heart rate (G). Each dot represents the number of repetitions. H–J: Pearson correlation of cardiac troponin T versus endothelial glycocalyx (eGC) height, eGC stiffness, and cortex (CTX) stiffness. Groups: sham-operated mice (SHAM), saline injection 24 hours before operation; SHAM + syndecan-1 (Syn-1), sham-operated mice with syndecan-1 treatment (4 μg/mouse; i.v. injection 24 hours before operation); AMI mice, subjected to left coronary artery ligation to induce myocardial infarction (saline injection 24 hours before operation); AMI + Syn-1 mice, subjected to left coronary artery ligation to induce myocardial infarction with syndecan-1 treatment (4 μg/mouse; i.v. injection 24 hours before AMI). Data are given as means ± SD (A–G). N = 5 individual mice per group (A–G). ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001 (one-way analysis of variance). bpm, beats per minute.