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Mean (±SEM) changes in oxygen levels in the NAc and SC space induced by iv fentanyl (20 μg/kg) before and after iv administration of naloxone (0.2 mg/kg). Top graph (A.) shows changes in oxygen levels during the entire session (μM) and lower graphs show relative changes (%) after each subsequent drug injection (B. fentanyl; C. naloxone; D. fentanyl and E. fentanyl). n = numbers of averaged tests. Filled symbols show values significantly different from the pre-injection baseline.
